| Abstract | Eight male, normolipidemic, non-obese subjects were given fenofibrate (F) (300 mg daily) for eight days (period F). After a wash-out period of four weeks, phenobarbital (P) (100 mg daily) was given for eight days (period P). At the end of this period, P was continued at the same dosage but F (300 mg daily) was added and both drugs were given simultaneously for a further eight-day period (period P + F). The plasma concentrations of lipids and the plasma activities of enzymes involved in the interconversion of plasma lipoproteins: lipoprotein lipase (LPL), hepatic lipase (HL) and lecithin: cholesterol acyltransferase (LCAT) were measured before and at the end of each period of treatment. Fenofibrate induced a decrease in the plasma concentration of triglycerides (TG), total cholesterol (TC), apoB and an increase in the plasma activities of LPL and LCAT. Phenobarbital induced a decrease in the plasma concentration of TC, HDL-C and LDL-C (with an unchanged HDL-C/LDL-C ratio) and in the plasma activity of LPL. Addition of P to F did not modify the hypolipidemic action of F but the increase of LPL activity during period P + F was found to be greater than that observed during period F. It is concluded that P does not modify the serum lipoprotein pattern in a way which can be considered as beneficial in terms of atherosclerosis. By measuring the serum concentration of unconjugated bilirubin, the plasma clearance of antipyrine and the urinary excretion of 6 beta-hydroxycortisol as parameters of hepatic microsomal induction, F appeared to be a slight inducer as compared with P. Thus, enzyme induction cannot explain the changes in serum lipoproteins induced by P and does not modify the hypolipidemic action of F. |
| Authors | F R Heller, J P Desager, C Harvengt
(Affiliation: Laboratory of Pharmacotherapy, Catholic University of Louvain, Brussels, Belgium.)
|
| Journal | International journal of clinical pharmacology, therapy, and toxicology
(Int J Clin Pharmacol Ther Toxicol)
Vol. 26
Issue 3
Pg. 138-42
(Mar 1988)
ISSN: 0174-4879 GERMANY, WEST |
| PMID | 3410596
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antilipemic Agents
- Lipids
- Propionates
- fenofibric acid
- Procetofen
- Phenobarbital
- Antipyrine
- Phosphatidylcholine-Sterol O-Acyltransferase
- Lipase
- Lipoprotein Lipase
|
| Topics |
- Adult
- Antilipemic Agents
(pharmacology)
- Antipyrine
(blood)
- Enzyme Induction
(drug effects)
- Humans
- Lipase
(blood)
- Lipids
(blood)
- Lipoprotein Lipase
(blood)
- Liver
(enzymology)
- Male
- Microsomes, Liver
(enzymology)
- Phenobarbital
(pharmacology)
- Phosphatidylcholine-Sterol O-Acyltransferase
(metabolism)
- Procetofen
(analogs & derivatives, pharmacology)
- Propionates
(pharmacology)
|
