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[Effect of quinazopyrine on the process of reparative regeneration].

Abstract
The effect of quinazopyrine on skin wound healing in rats was studied. Quinazopyrine was found to stimulate synthesis of nucleic acids, maturation of fibroblasts and to increase mechanical strength of the postoperative scar. This effect retains in animals with alloxan-induced diabetes. The wound-healing activity of quinazopyrine was higher than that of methyluracil, dimexide, pentoxyl, sodium nucleinate, potassium orotate and riboxine.
AuthorsV R Stets, V V Dunaev, I A Mazur, R S Siniak
JournalFarmakologiia i toksikologiia (Farmakol Toksikol) 1988 May-Jun Vol. 51 Issue 3 Pg. 67-9 ISSN: 0014-8318 [Print] Russia (Federation)
Vernacular TitleVliianie khinazopirina na protsessy reparativnoĭ regeneratsii.
PMID3410032 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Quinazolines
  • quinazopyrine
Topics
  • Animals
  • Diabetes Mellitus, Experimental (complications)
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Female
  • Lethal Dose 50
  • Male
  • Mice
  • Quinazolines (administration & dosage, pharmacology, toxicity)
  • Rats
  • Skin (drug effects)
  • Skin Physiological Phenomena
  • Staphylococcal Skin Infections (drug therapy)
  • Stimulation, Chemical
  • Wound Healing (drug effects)
  • Wound Infection (drug therapy)

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