[Effect of antiadrenergic and myotropic hypotensive agents on the blood kallikrein-kinin system in experimental hypertension].

Abstract

In the period of vasorenal hypertension formation in rats phase changes in the kallikrein-kinin system of the blood are observed: one month after kidney-skin anastomosis a significant increase of the levels of prekallikrein, kininogen and kallikrein inhibitor is noted and by the end of the second month a drastic decrease of the levels of these components occurs due to the "unregulated" activation of the kallikrein-kinin system of the blood. Antiadrenergic agents (reserpine, tropaphen) prescribed for treatment of hypertension prevent the development of the "unregulated" activation of the kallikrein-kinin system and reduce consumption of its components. These drugs are advisable to use under threat of the kallikrein-kinin system exhaustion. beta-adrenoblocking agent obsidan and myotropic drugs produce a significant enhancement of kallikreino- and kininogenesis, but the degree of activation of the processes is less pronounced than in untreated hypertensive rats.

• Authors: R N Abdullina, Iu D Davidenko, S M Fridman, G R Zaripova, R G Didenko
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1988 May-Jun Vol. 51 Issue 3 Pg. 38-41 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie antiadrenergicheskikh i miotropnykh gipotenzivnykh sredstv na kallikrein-kininovuiu sistemu krovi pri éksperimental'noĭ gipertenzii.
• PMID: 3410023 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antihypertensive Agents
• Kinins
• Sympatholytics
• Kallikreins

Topics

• Animals
• Antihypertensive Agents (therapeutic use)
• Drug Evaluation, Preclinical
• Hypertension, Renovascular (blood, drug therapy)
• Kallikreins (blood)
• Kinins (blood)
• Muscle, Smooth, Vascular (drug effects)
• Rats
• Sympatholytics (therapeutic use)
• Time Factors