Abstract | BACKGROUND: The guidelines for reducing surgical site infection in colorectal surgery recommend mechanical bowel preparation with oral antibiotics; however, this recommendation remains controversial. This study aimed to reveal the effect of oral antibiotics combined with mechanical bowel preparation in colorectal surgery. METHODS: This study was a nationwide population-based retrospective study. Data between January 1, 2016, and December 31, 2018, from the Korean National Health Insurance Service database were analyzed. Patients who underwent elective colorectal cancer surgery were included. RESULTS: A total of 20,740 patients were finally included, comprising 14,554 (70.2%) who underwent mechanical bowel preparation alone and 6186 (29.8%) who underwent mechanical bowel preparation with oral antibiotics. The mechanical bowel preparation alone group was older than the mechanical bowel preparation with oral antibiotics group (65.7 ± 11.9 vs. 64.7 ± 11.8 years, p < 0.001). Rectal cancer patients and patients who underwent open surgery were more likely to receive mechanical bowel preparation with oral antibiotics. Patients who underwent mechanical bowel preparation with oral antibiotics demonstrated lower surgical-site infection rate (2.9% vs. 9.4%, p < 0.001), shorter hospital stay (11.7 ± 5.5 vs. 13.5 ± 7.3 days, p < 0.001), and lower medical cost (US$7414 ± 2762 vs. US$7791 ± 3235, p < 0.001) than those who underwent mechanical bowel preparation alone. The 30-day readmission rates and mortality were not significantly different. CONCLUSIONS:
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Authors | Jun Ho Lee, Byung Kyu Ahn, Jiin Ryu, Kang Hong Lee |
Journal | International journal of colorectal disease
(Int J Colorectal Dis)
Vol. 36
Issue 9
Pg. 1929-1935
(Sep 2021)
ISSN: 1432-1262 [Electronic] Germany |
PMID | 34089359
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
Chemical References |
- Anti-Bacterial Agents
- Cathartics
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Topics |
- Administration, Oral
- Anti-Bacterial Agents
(therapeutic use)
- Antibiotic Prophylaxis
- Cathartics
- Elective Surgical Procedures
- Humans
- Preoperative Care
- Rectal Neoplasms
(drug therapy)
- Retrospective Studies
- Surgical Wound Infection
(epidemiology, etiology, prevention & control)
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