Efficacy and safety of low-dose corticosteroid with azathioprine in the treatment of elderly-onset IgA vasculitis with nephritis.

Abstract

The diagnosis of elderly-onset IgA vasculitis (IgAV) and its prognosis can be difficult to ascertain because of its rarity and the frequent presence of comorbidities. Furthermore, the treatment of elderly-onset IgAV remains controversial. We report a case of IgAV in an 87-year-old patient. Renal involvement was detected early during the IgAV follow-up. He was treated with low-dose corticosteroid and azathioprine, which led to a complete remission without any adverse effects. This suggests that precise intervention with early diagnosis and careful renal follow-up may prevent renal failure and that low-dose steroids with azathioprine can be an effective treatment for elderly-onset IgAV with nephritis.

• Authors: Hikaru Sugimoto, Yasuko Yamaguchi, Wako Yumura, Takashi Takei
• Journal: BMJ case reports (BMJ Case Rep) Vol. 14 Issue 6 (Jun 02 2021) ISSN: 1757-790X [Electronic] England
• PMID: 34083191 (Publication Type: Case Reports, Journal Article)
• Copyright: © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.

Chemical References

• Adrenal Cortex Hormones
• Immunoglobulin A
• Azathioprine

Topics

• Adrenal Cortex Hormones
• Aged
• Aged, 80 and over
• Azathioprine
• Humans
• IgA Vasculitis
• Immunoglobulin A
• Male
• Nephritis
• Vasculitis (drug therapy)