Lipid composition and cholesterol nucleation time in gallbladder bile of patients with cholesterol gallstones under choleretic treatment with Febuprol.

Abstract

The effect of a new potent choleretic drug (Febuprol) on lipid composition and cholesterol nucleation time in gallbladder bile was studied in 8 patients with cholesterol gallstones. Nine untreated patients with cholesterol cholecystolithiasis and functioning gallbladder served as controls. Under Febuprol treatment (3 X 100 mg for 6-10 days) mean concentrations of total bile acids (125.4 vs. 59.5 mmol/l), phospholipids (46.1 vs. 25.6 mmol/l) and total lipids (10.4 vs. 5.9 g/dl) were significantly higher (p less than 0.01) than in controls. No significant difference between both groups was calculated for the mean values of cholesterol (17.8 vs. 13.3 mmol/l), cholesterol saturation index (1.5 vs. 2.1) and cholesterol nucleation time (2.1 vs. 2.6 days). Our findings are compatible with a choleretic effect of Febuprol but no alteration of the rapid cholesterol crystallisation in gallbladder bile of patients with cholesterol gallstones was found.

• Authors: D Jüngst, G Brenner, E Pratschke, G Paumgartner
• Journal: Zeitschrift fur Gastroenterologie (Z Gastroenterol) Vol. 26 Issue 5 Pg. 275-8 (May 1988) ISSN: 0044-2771 [Print] Germany
• PMID: 3407249 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholagogues and Choleretics
• Phenyl Ethers
• Propanols
• 1-Propanol
• Cholesterol
• febuprol

Topics

• 1-Propanol (therapeutic use)
• Bile (drug effects, metabolism)
• Cholagogues and Choleretics (therapeutic use)
• Cholecystectomy
• Cholelithiasis (drug therapy, metabolism)
• Cholesterol (metabolism)
• Combined Modality Therapy
• Humans
• Lipid Metabolism
• Middle Aged
• Phenyl Ethers
• Propanols