Abstract |
Complex regional pain syndrome type 1 (CRPS-1) is a painful syndrome without effective treatment. In order to explore possible new treatments, we used an animal model of CRPS-1 to examine the effects of β- Citronellol (βCT), a monoterpene found in a variety of plants that has been shown to have analgesic effects. We aimed to assess its effects alone, and complexed with β- cyclodextrin (βCD), which has been previously used to enhance the effects of a number of medicines. The βCT-βCD was characterized physiochemically using high performance liquid chromatography (HPLC) and differential scanning calorimetry (DSC) and shown to have 80% efficiency. In the animal model, Swiss mice were treated with βCT, βCT-βCD, vehicle, pregabalin or sham and evaluated for hyperalgesia and motor coordination. Inflammatory mediators were measured by Western blot or ELISA and the descending pain pathway by immunofluorescence. βCT was shown to have an anti-hyperalgesic effect (without affecting motor coordination) that reduced inflammatory mediators and activated the descending pain pathway, and these effects were increased with complexation in βCD. Our results showed βCT-βCD to be a promising treatment for CRPS-1.
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Authors | Priscila L Santos, Thallita K Rabelo, João P S C F Matos, Klécia S Anjos, Marlange A O Melo, Yasmim M B G Carvalho, Bruno S Lima, Paula P Menezes, Adriano A S Araújo, Laurent Picot, Jackson R G S Almeida, Renan G Brito, Lucindo J Quintans-Júnior |
Journal | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
(Food Chem Toxicol)
Vol. 153
Pg. 112260
(Jul 2021)
ISSN: 1873-6351 [Electronic] England |
PMID | 34051299
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Elsevier Ltd. All rights reserved. |
Chemical References |
- Acyclic Monoterpenes
- Analgesics
- Anti-Inflammatory Agents
- Drug Carriers
- Food Ingredients
- NF-kappa B p50 Subunit
- Tumor Necrosis Factor-alpha
- beta-Cyclodextrins
- Nfkb1 protein, mouse
- Ptgs2 protein, mouse
- Cyclooxygenase 2
- citronellol
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Topics |
- Acyclic Monoterpenes
(therapeutic use)
- Analgesics
(therapeutic use)
- Animals
- Anti-Inflammatory Agents
(therapeutic use)
- Cyclooxygenase 2
(metabolism)
- Drug Carriers
(chemistry)
- Food Ingredients
- Hyperalgesia
(drug therapy)
- Male
- Mice
- NF-kappa B p50 Subunit
(metabolism)
- Reflex Sympathetic Dystrophy
(drug therapy)
- Spinal Cord Dorsal Horn
(drug effects)
- Tumor Necrosis Factor-alpha
(metabolism)
- beta-Cyclodextrins
(chemistry)
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