2', 5' oligo (A) synthetase levels in interferon-sensitive or resistant breast cancer cells.

Abstract

The levels of 2', 5' oligo (A) synthetase increase 15-fold when T47D cells are treated with human interferon or with interferon inducers. The results also show that interferon-treated T47D cells contain high levels of 2', 5' oligo (A) synthetase which upon incubation with ATP produces adenine oligonucleotides which are predominantly trimers. In contrast, MCF-7 and BT20 cells whether treated with interferon or not exhibit low 2', 5' oligo (A) synthetase activity.

• Authors: A Kortsaris
• Journal: Microbiologica (Microbiologica) Vol. 11 Issue 2 Pg. 111-7 (Apr 1988) ISSN: 0391-5352 [Print] Italy
• PMID: 3405096 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interferon Type I
• Poly A
• Poly U
• Poly C
• 2',5'-Oligoadenylate Synthetase

Topics

• 2',5'-Oligoadenylate Synthetase (biosynthesis)
• Breast Neoplasms (enzymology)
• Enzyme Induction
• Female
• Humans
• Interferon Type I (pharmacology)
• Poly A (pharmacology)
• Poly C (pharmacology)
• Poly U (pharmacology)
• Tumor Cells, Cultured