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Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers.

Abstract
Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.
AuthorsZoë Rachael Goddard, Andrew Michael Beekman, Marco M D Cominetti, Maria A O'Connell, Isabelle Chambrier, Michael J Cook, María J Marín, David A Russell, Mark Searcey
JournalRSC medicinal chemistry (RSC Med Chem) Vol. 12 Issue 2 Pg. 288-292 (Nov 19 2020) ISSN: 2632-8682 [Electronic] England
PMID34041483 (Publication Type: Journal Article)
CopyrightThis journal is © The Royal Society of Chemistry.

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