Toluene-induced leukodystrophy from glue sniffing.

Abstract

A 33-year-old man with a history of chronic toluene abuse through glue sniffing, developed tremors, cerebellar signs and cognitive decline. MR scan of the brain showed global cerebral and cerebellar atrophy with symmetrical T2-weighted hypointensities in the basal ganglia, thalami and midbrain. After stopping glue sniffing, his tremors, ataxia of gait, speech and cognition partially improved. Early recognition and intervention of toluene-induced leukodystrophy could prevent ongoing morbidity and premature mortality.

• Authors: Yue Hui Lau, Ahmad Shahir Mawardi, Norzaini Rose Zain, Shanthi Viswanathan
• Journal: Practical neurology (Pract Neurol) Vol. 21 Issue 5 Pg. 439-441 (Oct 2021) ISSN: 1474-7766 [Electronic] England
• PMID: 34039751 (Publication Type: Case Reports, Journal Article)
• Copyright: © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.

Chemical References

• Toluene

Topics

• Adult
• Basal Ganglia
• Brain
• Humans
• Inhalant Abuse (complications)
• Male
• Substance-Related Disorders
• Toluene (adverse effects)