Impact of emollient therapy for preterm infants in the neonatal period on child neurodevelopment in Bangladesh: an observational cohort study.

Abstract

BACKGROUND:

Topical treatment with sunflower seed oil (SSO) or Aquaphor® reduced sepsis and neonatal mortality in hospitalized preterm infants <33 weeks' gestational age in Bangladesh. We sought to determine whether the emollient treatments improved neurodevelopmental outcomes during early childhood.

METHODS:

497 infants were randomized to receive SSO, Aquaphor®, or neither through the neonatal period or hospital discharge. 159 infant survivors were enrolled in the longitudinal follow-up study using a validated Rapid Neurodevelopmental Assessment tool and the Bayley Scales of Infant Development II (BSID II) administered at three-monthly intervals for the first year and thereafter at six-monthly intervals. Lowess smoothing was used to display neurodevelopmental status across multiple domains by age and treatment group, and Generalized Estimating Equations (GEE) were used to compare treatment groups across age points.

RESULTS:

123 children completed at least one follow-up visit. Lowess graphs suggest that lower proportions of children who received massage with either SSO or Aquaphor® had neurodevelopmental delays than control infants in a composite outcome of disabilities. In GEE analysis, infants receiving SSO showed a significant protective effect on the development of fine motor skills [odds ratio (OR) 0.92, 95% confidence interval (CI) 0.86-0.98, p=0.006]. The Psychomotor Development Index (PDI) in the BSID II showed significantly lower disability rates in the Aquaphor group (23.6%) compared to the control (55.2%) (OR 0.21, 95% CI 0.06-0.72, p=0.004).

CONCLUSIONS:

Emollient massage of very preterm, hospitalized newborn infants improved some child neurodevelopmental outcomes over the first 2 years of follow-up. Findings warrant further confirmatory research.

TRIAL REGISTRATION:

ClinicalTrials.gov (98-04-21-03-2) under weblink https://clinicaltrials.gov/ct2/show/NCT00162747.

• Authors: Gary L Darmstadt, Naila Z Khan, Summer Rosenstock, Humaira Muslima, Monowara Parveen, Wajeeha Mahmood, A S M Nawshad Uddin Ahmed, M A K Azad Chowdhury, Scott Zeger, Samir K Saha
• Journal: Journal of health, population, and nutrition (J Health Popul Nutr) Vol. 40 Issue 1 Pg. 24 (05 26 2021) ISSN: 2072-1315 [Electronic] Bangladesh
• PMID: 34039435 (Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Emollients

Topics

• Bangladesh
• Child
• Child Development
• Child, Preschool
• Emollients (therapeutic use)
• Follow-Up Studies
• Humans
• Infant
• Infant, Newborn
• Infant, Premature
• Infant, Very Low Birth Weight