Actinoplanones C, D, E, F and G, new cytotoxic polycyclic xanthones from Actinoplanes sp.

Abstract

Our previous finding of strong cytotoxic polycyclic xanthones, actinoplanones A (1) and B (2), in the culture broth of Actinoplanes sp. R-304 stimulated us to isolate further five new cytotoxic polycyclic xanthones which were named actinoplanones C (3), D (4), E (5), F (6) and G (7) from the broth. Actinoplanones C (3) and G (7) showed very strong cytotoxicity against HeLa cells at less than 0.00004 microgram/ml dosage (IC50). The structures of 3-7 were varieties of 1 for the N-2 and C-4 substituents. All or several actinoplanones showed strong antimicrobial activities against bacteria and the rice blast fungus. Actinoplanone A (1) was tested for cytotoxicity against various tumor cells and for inhibitory effect on HeLa cell macromolecular synthesis, and 1 exhibited strong cytotoxicity against the cells and inhibitory action on DNA synthesis.

• Authors: K Kobayashi, C Nishino, J Ohya, S Sato, T Mikawa, Y Shiobara, M Kodama
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 41 Issue 6 Pg. 741-50 (Jun 1988) ISSN: 0021-8820 [Print] England
• PMID: 3403368 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Antifungal Agents
• Xanthenes
• actinoplanone F
• actinoplanone C
• actinoplanone D
• actinoplanone G
• actinoplanone E
• DNA

Topics

• Actinomycetales (metabolism)
• Antibiotics, Antineoplastic (isolation & purification, pharmacology)
• Antifungal Agents (isolation & purification, pharmacology)
• Chemical Phenomena
• Chemistry
• DNA (biosynthesis)
• Protein Biosynthesis
• Structure-Activity Relationship
• Xanthenes (isolation & purification, pharmacology)