Collagen biosynthesis in a case of infantile myofibromatosis.

Abstract	Cells from a skin nodule from a patient with a recurrent form of familial myofibromatosis were cultivated in vitro. A metabolic study showed that these cells behaved like fibroblasts with collagen synthesis, a normal percentage of type III collagen, hydroxylation rate and the ability to contract a collagen gel. The main disturbances were the decreased synthesis and increased cell multiplication rate after a lag phase. This behavior was compared with that of a fibroblast culture from normal skin.
Authors	A Chamson, J Frey, D Frappaz, G Damon, F Freycon, B Lauras
Journal	Clinical physiology and biochemistry (Clin Physiol Biochem) Vol. 6 Issue 2 Pg. 57-63 ( 1988) ISSN: 0252-1164 [Print] Germany
PMID	3402159 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	DNA, Neoplasm Neoplasm Proteins Collagen
Topics	Collagen (biosynthesis) DNA, Neoplasm (analysis) Fibroma (genetics, metabolism, pathology) Humans Infant Kinetics Leiomyoma (genetics, metabolism, pathology) Male Neoplasm Proteins (analysis, biosynthesis) Skin Neoplasms (genetics, metabolism, pathology) Tumor Cells, Cultured

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