Abstract |
The expression of desmin and vimentin in 35 " smooth muscle tumors" of the digestive tract was investigated using formalin-fixed and paraffin-embedded materials and the indirect immunoperoxidase method. Fourteen of 15 esophageal tumors and two of 15 gastric tumors were categorized as benign leiomyoma with low cellularity, and immunohistochemically were desmin-positive and vimentin-negative as were normal muscle layers of the digestive tract. The remaining tumors showed moderate to high cellularity: Six tumors seemed to be malignant on the basis of frequent mitosis and/or nuclear atypia, while 11 were considered to be of borderline malignancy. This cellular tumor group exhibited consistent vimentin immunoreactivity, but desmin was negative or only weakly and/or focally positive. S-100 protein was fundamentally negative in these tumors. The pitfalls of studying desmin immunohistochemistry as a routine diagnostic tool in surgical pathology are discussed.
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Authors | Y Tsutsumi, H Kubo |
Journal | Acta pathologica japonica
(Acta Pathol Jpn)
Vol. 38
Issue 4
Pg. 455-69
(Apr 1988)
ISSN: 0001-6632 [Print] Australia |
PMID | 3400467
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Desmin
(metabolism)
- Digestive System Neoplasms
(metabolism, pathology)
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Muscle, Smooth
- Neoplasms, Muscle Tissue
(metabolism, pathology)
- Vimentin
(metabolism)
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