Pharmacokinetics of PTT-119 in man.

Abstract

The pharmacokinetics of PTT-119, a new alkylating agent, was studied in 8 advanced cancer patients. PTT-119 disappeared rapidly from plasma after administration at a dose of 3 mg/kg by i.v. bolus injection. The HPLC method shows plasma levels of m-bis (dichloroethyl)amino-phenyl-L-alanine which is the major metabolite of PPT-119. Elimination of the drug from plasma can be described by a one-compartment model. Mean values of 77.8 min for the half-life, 510.8 ml/min for the total plasma clearance and 0.69 l/kg for the volume of distribution were found.

• Authors: F Pannuti, G Coppi, F Borella, A Martoni, L Urbano, B Melotti
• Journal: Chemioterapia : international journal of the Mediterranean Society of Chemotherapy (Chemioterapia) Vol. 7 Issue 2 Pg. 113-6 (Apr 1988) ISSN: 0392-906X [Print] Italy
• PMID: 3396115 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Nitrogen Mustard Compounds
• ambamustine

Topics

• Aged
• Antineoplastic Agents (pharmacokinetics, therapeutic use)
• Humans
• Male
• Middle Aged
• Neoplasm Metastasis
• Nitrogen Mustard Compounds (pharmacokinetics, therapeutic use)