[A case of advanced breast cancer successfully treated with combined tamoxifen and epitiostanol].

Abstract

A patient with stage IV advanced breast cancer with multiple metastasis (bones of the whole body, lungs) were treated by ovariectomy, administration of an non-steroidal antiestrogen (tamoxifen) and mild chemotherapeutic drugs, with favorable results. After four years, however, the patient had a relapse of the cancer. A steroidal antiestrogen (epitiostanol) was then administered with satisfactory results. When a breast cancer relapse occurs in patients once treated successfully with endocrinotherapy, a different form of endocrinotherapy should be tried. There is a possibility that the mechanism of action of Epitiostanol, which is regarded as a steroidal antiestrogen, is different from that of tamoxifen in which an estrogen receptor (ER) system is included.

• Authors: Y Konishi, T Morimoto, K Komaki, T Yamakawa, N Mituyama, T Tanaka, Y Oomine, Y Monden
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 15 Issue 7 Pg. 2163-7 (Jul 1988) ISSN: 0385-0684 [Print] Japan
• PMID: 3395140 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Androstanols
• Estrogen Antagonists
• Tamoxifen
• epitiostanol

Topics

• Androstanols (administration & dosage, therapeutic use)
• Breast Neoplasms (drug therapy, pathology, therapy)
• Combined Modality Therapy
• Drug Therapy, Combination
• Estrogen Antagonists (administration & dosage, therapeutic use)
• Female
• Humans
• Middle Aged
• Neoplasm Metastasis
• Neoplasm Recurrence, Local (drug therapy)
• Ovariectomy
• Tamoxifen (administration & dosage, therapeutic use)