Abstract | PURPOSE: METHODS: A literature review of anatomical measures of disease activity was conducted. RESULTS: Treatment goals for neovascular age-related macular degeneration include improving/maintaining vision by drying the retina, and several analyses have evaluated the relationship between visual function and anatomy. The change in retinal thickness has been found to correlate with the change in the visual acuity, and variation in retinal thickness may predict visual acuity outcomes. In addition, specific fluid compartments may have different prognostic values. For example, the presence of intraretinal fluid has been associated with poorer visual acuity, whereas the presence of subretinal fluid has been associated with better visual acuity. Retinal fluid and thickness are important for selecting dosing interval durations in clinical trials and clinical practice. CONCLUSION:
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Authors | Peter K Kaiser, Charles C Wykoff, Rishi P Singh, Arshad M Khanani, Diana V Do, Hersh Patel, Nikhil Patel |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 41
Issue 8
Pg. 1579-1586
(Aug 01 2021)
ISSN: 1539-2864 [Electronic] United States |
PMID | 33949342
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Opthalmic Communications Society, Inc. |
Topics |
- Fluorescein Angiography
(methods)
- Fundus Oculi
- Humans
- Prognosis
- Severity of Illness Index
- Subretinal Fluid
(diagnostic imaging)
- Tomography, Optical Coherence
(methods)
- Visual Acuity
- Wet Macular Degeneration
(diagnosis)
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