Glioblastoma is one of the most common malignant
tumors in the central nervous system. Due to the high plasticity, heterogeneity and complexity of the tumor microenvironment, these
tumors are resistant to almost all therapeutic strategies when they reach an advanced stage. Along with being a unique and effective way to kill
cancer cells,
tumor-treating fields (TTFields) has emerged as a breakthrough among
glioblastoma therapies since the advent of
temozolomide (TMZ), and the combination of these treatments has gradually been promoted and applied in the clinic. The combination of TTFields with other
therapies is particularly suitable for this type of "cold"
tumors and has attracted a large amount of attention from clinicians and researchers in the era of
cancer cocktail
therapy. Here, we introduced the current treatment regimen for
glioblastoma, highlighting the unique advantages of TTFields in the treatment of
glioblastoma. Then, we summarized current
glioblastoma clinical trials that combine TTFields and other
therapies. In addition, the main and potential mechanisms of TTFields were introduced to further understand the rationale for each combination
therapy. Finally, we focused on the most advanced technologies applied in
glioblastoma research and treatment and the prospect of their combination with TTFields. This review provides a unique overview of
glioblastoma treatment.