Vertigo is not itself a disease, but rather a symptom of various syndromes and disorders that jeopardize balance function, which is essential for daily activities. It is an abnormal sensation of motion that usually occurs in the absence of motion, or when a motion is sensed inaccurately. Due to the complexity of the etiopathogenesis of
vertigo, many pharmacological treatments have been tested for efficacy on
vertigo. Among these drugs,
cinnarizine, usually given together with
dimenhydrinate, appears to be the first-line
pharmacotherapy for the management of
vertigo and inner ear disorders. Based on these considerations, the present non-interventional study aimed to investigate the clinical efficacy and tolerability of a fixed combination of
cinnarizine (20 mg) and
dimenhydrinate (40 mg) in patients suffering from
vertigo-related symptoms. To this end, we enrolled 120 adults-70 males, and 50 females-with an average age of 64 years. Before beginning pharmacological treatment, all patients were screened for the intensity of
vertigo,
dizziness, and concomitant symptoms through the Visual Scale of
Dizziness Disorders and
Dizziness Handicap Inventory scales. At the end of the anamnestic evaluation, patients received the fixed-dose combination of
cinnarizine (20 mg) plus
dimenhydrinate (40 mg) 3 times daily, for 60 days. The results of this study provide further insight regarding the efficacy of the fixed combination when used to reduce symptoms of vestibular
vertigo of central and/or peripheral origin, after both the 15- and 60-day
therapies. Independent of the type of
vertigo, the fixed combination was able to reduce
dizziness- and
vertigo-associated symptoms in more than 75% of all patients treated, starting from 15 days of
therapy, and improving 60 days after starting the
therapy. Interestingly, we also found differences between male and female patients in the framework of the pharmacological effects of
therapy. This study provides further details concerning the therapeutic efficacy of the fixed combination of
cinnarizine and
dimenhydrinate, and also focuses attention on the possibility that these drugs could act in a gender-specific manner, paving the way for further research.