Nanoparticle-based applications for cervical cancer treatment in drug delivery, gene editing, and therapeutic cancer vaccines.

Abstract

Cervical cancer is a leading cause of gynecological tumor related deaths worldwide. The applications of conventional approaches such as chemoradiotherapy and surgery are restricted due to their side effects and drug resistances. Although immune checkpoint inhibitors (ICIs) have emerged as novel choices, their clinical response rates are rather limited. To date there is a lack of effective treatment regimens for patients with metastatic or recurrent cervical cancer. Recently nanomaterials like liposomes, dendrimers, and polymers are considered as promising delivery carriers with advantages of tumor-specific administration, reduced toxicity, and improved biocompatibility. Here, we review the applications of nanoparticles in the fields of drug delivery, CRISPR based genome-editing and therapeutic vaccines in cervical cancer treatment. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

• Authors: Peijie Zhou, Wei Liu, Yong Cheng, Dong Qian
• Journal: Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology (Wiley Interdiscip Rev Nanomed Nanobiotechnol) Vol. 13 Issue 5 Pg. e1718 (09 2021) ISSN: 1939-0041 [Electronic] United States
• PMID: 33942532 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2021 The Authors. WIREs Nanomedicine and Nanobiotechnology published by Wiley Periodicals LLC.

Chemical References

• Cancer Vaccines
• Liposomes

Topics

• Cancer Vaccines (therapeutic use)
• Drug Delivery Systems
• Female
• Gene Editing
• Humans
• Liposomes
• Nanoparticles
• Uterine Cervical Neoplasms (therapy)