State-of-Art of Cellular Therapy for Acute Leukemia.

Abstract

With recent clinical breakthroughs, immunotherapy has become the fourth pillar of cancer treatment. Particularly, immune cell-based therapies have been envisioned as a promising treatment option with curative potential for leukemia patients. Hence, an increasing number of preclinical and clinical studies focus on various approaches of immune cell-based therapy for treatment of acute leukemia (AL). However, the use of different immune cell lineages and subsets against different types of leukemia and patient disease statuses challenge the interpretation of the clinical applicability and outcome of immune cell-based therapies. This review aims to provide an overview on recent approaches using various immune cell-based therapies against acute B-, T-, and myeloid leukemias. Further, the apparent limitations observed and potential approaches to overcome these limitations are discussed.

• Authors: Jong-Bok Lee, Daniel Vasic, Hyeonjeong Kang, Karen Kai-Lin Fang, Li Zhang
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 22 Issue 9 (Apr 27 2021) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 33925571 (Publication Type: Journal Article, Review)

Chemical References

• Receptors, Chimeric Antigen

Topics

• Acute Disease
• Cell- and Tissue-Based Therapy
• Humans
• Immunotherapy
• Immunotherapy, Adoptive (methods, trends)
• Killer Cells, Natural (immunology)
• Leukemia, Myeloid, Acute (metabolism, therapy)
• Leukemia, T-Cell (metabolism, therapy)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (metabolism, therapy)
• Receptors, Chimeric Antigen (metabolism)
• T-Lymphocytes (immunology)