Abstract |
Biosynthetic patterns of 18-OH-deoxycorticosterone (18-OH-DOC) and corticosterone (B) in adrenal tissue of Wistar-rats and two rat strains with salt-dependent hypertension (Dahl-, Sabra-rats) were measured by means of quantitative HPLC-analysis. The relative activity of 18-hydroxylation is expressed as the ratio 18- OH-DOC/18- OH-DOC + B, in the following called Q. Wistar-rats show a constant product ratio Q of 0.40 +/- 0.01. Dahl-rats, however, exhibit typical differences between the two substrains. Adrenal tissue of salt-resistant (Dahl-R) rats produces significantly less 18-OH-DOC than tissue from salt-sensitive (Dahl-S) rats: Q = 0.17 +/- 0.01 (Dahl-R) vs. Q = 0.37 +/- 0.01 (Dahl-S). No such difference was observed between the two Sabra-substrains. This indicates, that other mechanisms than an altered 11 beta-18-hydroxylation are involved in the salt-dependent hypertension of Sabra-rats.
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Authors | S Wohlfeil, D Neuser, F J Morich |
Journal | Clinical and experimental hypertension. Part A, Theory and practice
(Clin Exp Hypertens A)
Vol. 10
Issue 4
Pg. 617-27
( 1988)
ISSN: 0730-0077 [Print] United States |
PMID | 3390964
(Publication Type: Journal Article)
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Chemical References |
- 18-hydroxydeoxycorticosterone
- Desoxycorticosterone
- Sodium Chloride
- Corticosterone
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Topics |
- Adrenal Glands
(metabolism)
- Animals
- Corticosterone
(biosynthesis)
- Desoxycorticosterone
(analogs & derivatives, biosynthesis)
- Hypertension
(etiology, metabolism)
- In Vitro Techniques
- Rats
- Rats, Inbred SHR
- Rats, Inbred Strains
- Sodium Chloride
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