Biosynthesis of 18-hydroxydeoxycorticosterone and corticosterone in adrenal tissue of rat strains with salt-dependent hypertension.

Abstract

Biosynthetic patterns of 18-OH-deoxycorticosterone (18-OH-DOC) and corticosterone (B) in adrenal tissue of Wistar-rats and two rat strains with salt-dependent hypertension (Dahl-, Sabra-rats) were measured by means of quantitative HPLC-analysis. The relative activity of 18-hydroxylation is expressed as the ratio 18-OH-DOC/18-OH-DOC + B, in the following called Q. Wistar-rats show a constant product ratio Q of 0.40 +/- 0.01. Dahl-rats, however, exhibit typical differences between the two substrains. Adrenal tissue of salt-resistant (Dahl-R) rats produces significantly less 18-OH-DOC than tissue from salt-sensitive (Dahl-S) rats: Q = 0.17 +/- 0.01 (Dahl-R) vs. Q = 0.37 +/- 0.01 (Dahl-S). No such difference was observed between the two Sabra-substrains. This indicates, that other mechanisms than an altered 11 beta-18-hydroxylation are involved in the salt-dependent hypertension of Sabra-rats.

• Authors: S Wohlfeil, D Neuser, F J Morich
• Journal: Clinical and experimental hypertension. Part A, Theory and practice (Clin Exp Hypertens A) Vol. 10 Issue 4 Pg. 617-27 ( 1988) ISSN: 0730-0077 [Print] United States
• PMID: 3390964 (Publication Type: Journal Article)

Chemical References

• 18-hydroxydeoxycorticosterone
• Desoxycorticosterone
• Sodium Chloride
• Corticosterone

Topics

• Adrenal Glands (metabolism)
• Animals
• Corticosterone (biosynthesis)
• Desoxycorticosterone (analogs & derivatives, biosynthesis)
• Hypertension (etiology, metabolism)
• In Vitro Techniques
• Rats
• Rats, Inbred SHR
• Rats, Inbred Strains
• Sodium Chloride