Abstract | OBJECTIVES: BACKGROUND: Whether the periprocedural use of bivalirudin as compared with UFH in anemic patients undergoing TAVR has an impact on outcomes remains unknown. METHODS: RESULTS: Among 798 patients with available baseline hemoglobin levels, 427 (54%) were anemic of whom 221 (52%) received bivalirudin. There were no significant differences in NACE and major bleeding at 30 days between patients with and without anemia, irrespective of the type of anticoagulant used (pinteraction = 0.71 for NACE, pinteraction = 1.0 for major bleeding). However, anemic patients had a higher risk of major vascular complications (adjusted OR 2.43, 95% CI 1.42-4.16, p = 0.001), and acute kidney injury (adjusted OR 1.74, 95% CI 1.16-2.59, p = 0.007) compared to non-anemic patients at 30 days. CONCLUSIONS:
Anemia was not associated with a higher risk of NACE or major bleeding at 30 days after TAVR without modification of the treatment effects of periprocedural anticoagulation with bivalirudin versus UFH.
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Authors | Victor Razuk, Anton Camaj, Davide Cao, Johny Nicolas, Christian Hengstenberg, Samantha Sartori, Zhongjie Zhang, David Power, Frans Beerkens, Mauro Chiarito, Nicolas Meneveau, Christophe Tron, Nicolas Dumonteil, Julian D Widder, Markus Ferrari, Roberto Violini, Pieter R Stella, Raban Jeger, Prodromos Anthopoulos, Roxana Mehran, George D Dangas |
Journal | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
(Catheter Cardiovasc Interv)
Vol. 98
Issue 6
Pg. E870-E880
(11 15 2021)
ISSN: 1522-726X [Electronic] United States |
PMID | 33909348
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | © 2021 Wiley Periodicals LLC. |
Chemical References |
- Antithrombins
- Nitriles
- Heparin
- tetrachloroisophthalonitrile
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Topics |
- Anemia
(diagnosis)
- Antithrombins
- Aortic Valve Stenosis
(diagnostic imaging, surgery)
- Female
- Heparin
- Humans
- Male
- Nitriles
- Transcatheter Aortic Valve Replacement
(adverse effects)
- Treatment Outcome
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