Relationship between small dense low-density lipoprotein cholesterol with carotid plaque in Chinese individuals with abnormal carotid artery intima-media thickness.

Abstract

AIM:

To investigate the relationship of small dense low-density lipoprotein cholesterol (sdLDL-C) to carotid artery intima-media thickness (CA-IMT) and carotid plaque (CAP) in Chinese general population, and to evaluate whether sdLDL-C could be an independent risk factor for individuals with subclinical atherosclerosis.

METHODS:

A total of 729 subjects were randomly collected from consecutive individuals from April 2019 to April 2020 for an annual health checkup. CA-IMT > 1.0 mm was defined as abnormal IMT. Plaque stability was measured by ultrasound examination based on the property of the echo. And sdLDL-C levels were detected by LipoPrint system. Multivariate logistic regression analysis was performed to identify factors associated with CA-IMT and carotid plaque.

RESULTS:

The abnormal IMT group had significantly higher sdLDL-C levels than control group (p < 0.0001). And sdLDL-C levels were significantly positively correlated with IMT value (r = 0.1396, p = 0.0021) and presence of carotid plaque (r = 0.14, p = 0.002) in the subjects with abnormal IMT. In addition, subjects with higher levels of sdLDL-C (r = 0.11, p = 0.035) tended to have unstable CAP. After adjustment for age, gender and blood glucose, sdLDL-C level was an independent risk factor of the presence of CAP (OR = 1.59, 95% CI: 1.02-1.83, p = 0.034) in subjects with abnormal IMT.

CONCLUSION:

SdLDL-C is an independent risk factor of the occurrence of CAP in the Chinese subjects with abnormal IMT. Our findings provide supporting evidence that sdLDL-C might be an alternative way to predict CVD in early stage.

• Authors: Fang Liu, Zheng Wang, Xia Cao, Yingxia Pan, Erqiang Zhang, Jiahuan Zhou, Lina Zheng
• Journal: BMC cardiovascular disorders (BMC Cardiovasc Disord) Vol. 21 Issue 1 Pg. 216 (04 27 2021) ISSN: 1471-2261 [Electronic] England
• PMID: 33906606 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Cholesterol, LDL

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Carotid Arteries (diagnostic imaging)
• Carotid Artery Diseases (diagnostic imaging, epidemiology)
• Carotid Intima-Media Thickness
• China (epidemiology)
• Cholesterol, LDL (blood)
• Dyslipidemias (blood, diagnosis, epidemiology)
• Female
• Humans
• Male
• Middle Aged
• Particle Size
• Plaque, Atherosclerotic
• Predictive Value of Tests
• Retrospective Studies
• Risk Assessment
• Risk Factors
• Ultrasonography, Doppler, Color
• Young Adult