An antineuronal autoantibody in paraneoplastic opsoclonus.

Abstract

Sera from 7 patients with paraneoplastic opsoclonus were examined for antineuronal autoantibodies. An antibody against neuronal nuclei was found in serum from a patient with breast cancer, opsoclonus, and ataxia. This antibody recognized 53- to 61-kDa and 79- to 84-kDa antigens in immunoblots of neurons. Antineuronal antibodies were not found in other patients with paraneoplastic opsoclonus.

• Authors: C Budde-Steffen, N E Anderson, M K Rosenblum, F Graus, D Ford, B J Synek, S H Wray, J B Posner
• Journal: Annals of neurology (Ann Neurol) Vol. 23 Issue 5 Pg. 528-31 (May 1988) ISSN: 0364-5134 [Print] United States
• PMID: 3389761 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies

Topics

• Adult
• Autoantibodies (blood)
• Breast Neoplasms (complications, immunology)
• Carcinoma (complications, immunology)
• Cerebellum (immunology)
• Eye Movements
• Female
• Humans
• Infant
• Male
• Middle Aged
• Molecular Weight
• Neurons (immunology)
• Paraneoplastic Syndromes (immunology)