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Species differences in butadiene metabolism between mouse and rat.

Abstract
Studies on inhalation pharmacokinetics of 1,3-butadiene were conducted in mice (B6C3F1) and rats (Sprague-Dawley) to investigate the considerable differences in the susceptibility of both species to butadiene-induced carcinogenesis. In rats and mice metabolism of 1,3-butadiene to 1,2-epoxybutene-3 follows saturation kinetics. "Linear" (first-order) pharmacokinetics apply at exposure concentrations below 1000 ppm 1,3-butadiene. Saturation of butadiene metabolism is observed at atmospheric concentrations of about 2000 ppm butadiene. In the lower concentration range where first-order metabolism applies, metabolic clearance of inhaled 1,3-butadiene per kg body weight was 7300 ml (gas volume) x hr-1 for mice and 4500 ml x hr-1 for rats. The calculated maximal metabolic elimination rates (Vmax - conditions) were 400 mumol x hr-1 x kg-1 for mice and 220 mumol x hr-1 x kg-1 for rats. This shows that 1,3-butadiene is metabolized by mice at about twice the rate of rats, under conditions of both low and high exposure concentrations.
AuthorsR J Laib, J G Filser, R Kreiling
JournalAnnals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 534 Pg. 663-70 ( 1988) ISSN: 0077-8923 [Print] United States
PMID3389683 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Butadienes
Topics
  • Administration, Inhalation
  • Animals
  • Butadienes (metabolism, pharmacokinetics)
  • Kinetics
  • Male
  • Mice
  • Rats
  • Rats, Inbred Strains
  • Species Specificity

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