[Personal experiences with phenoxybenzamine (Dibenzyran) in the treatment of functional disorders of bladder emptying].

Abstract

The influence of phenoxybenzamine on micturition was examined in 46 patients with functional bladder neck obstruction. Due to blockade of the alpha-adrenergic receptors at the bladder neck an increase of the maximal flow rate from a mean value of 13.6 to 24.6 ml s-1 was found during the treatment. In addition, there was a relaxation of the functional urethral length and a reduction of the maximal urethral closure pressure from 96.3 to 74.4 cm H2O. The most significant changes resulting from the application of Dibenzyran were observed in the neuropathic bladder with a reduction of the functional urethral length from 24.3 to 20.5 mm and a decrease of Pura max from 100.5 to 82.7 cm H2O. Furthermore, we achieved an increase of the maximal flow rate from 13.4 to 22.5 ml s-1.

• Authors: J Wehnert, S Sage
• Journal: Zeitschrift fur Urologie und Nephrologie (Z Urol Nephrol) Vol. 81 Issue 3 Pg. 153-8 (Mar 1988) ISSN: 0044-3611 [Print] Germany
• Vernacular Title: Unsere Erfahrungen mit Phenoxybenzamin (Dibenzyran) in der Behandlung funktioneller Blasenentleerungsstörungen.
• PMID: 3388995 (Publication Type: English Abstract, Journal Article)

Chemical References

• Phenoxybenzamine

Topics

• Humans
• Phenoxybenzamine (therapeutic use)
• Urethra (drug effects)
• Urinary Bladder (drug effects)
• Urinary Bladder, Neurogenic (drug therapy)
• Urination Disorders (drug therapy)
• Urodynamics (drug effects)