| Abstract | The influence of phenoxybenzamine on micturition was examined in 46 patients with functional bladder neck obstruction. Due to blockade of the alpha-adrenergic receptors at the bladder neck an increase of the maximal flow rate from a mean value of 13.6 to 24.6 ml s-1 was found during the treatment. In addition, there was a relaxation of the functional urethral length and a reduction of the maximal urethral closure pressure from 96.3 to 74.4 cm H2O. The most significant changes resulting from the application of Dibenzyran were observed in the neuropathic bladder with a reduction of the functional urethral length from 24.3 to 20.5 mm and a decrease of Pura max from 100.5 to 82.7 cm H2O. Furthermore, we achieved an increase of the maximal flow rate from 13.4 to 22.5 ml s-1. |
| Authors | J Wehnert, S Sage
(Affiliation: Klinik für Urologie, Medizinischen Akademie Carl Gustav Carus Dresden.)
|
| Journal | Zeitschrift für Urologie und Nephrologie
(Z Urol Nephrol)
Vol. 81
Issue 3
Pg. 153-8
(Mar 1988)
ISSN: 0044-3611 GERMANY, EAST |
| Vernacular Title | Unsere Erfahrungen mit Phenoxybenzamin (Dibenzyran) in der Behandlung funktioneller Blasenentleerungsstörungen. |
| PMID | 3388995
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
|
| Topics |
- Humans
- Phenoxybenzamine
(therapeutic use)
- Urethra
(drug effects)
- Urinary Bladder
(drug effects)
- Urinary Bladder, Neurogenic
(drug therapy)
- Urination Disorders
(drug therapy)
- Urodynamics
(drug effects)
|
