Considerable breakthroughs in the treatment of malignant
tumors using antibody drugs, especially immunomodulating
monoclonal antibodies (mAbs), have been made in the past decade. Despite technological advancements in antibody design and manufacture, multiple challenges face antibody-mediated
cancer therapy, such as instability in vivo, poor
tumor penetration, limited response rate, and undesirable off-target cytotoxicity. In recent years, an increasing number of
biomaterials-based delivery systems have been reported to enhance the antitumor efficacy of antibody drugs. This review summarizes the advances and breakthroughs in integrating
biomaterials with therapeutic
antibodies for enhanced
cancer therapy. A brief introduction to the principal mechanism of antibody-based
cancer therapy is first established, and then various antibody immobilization strategies are provided. Finally, the current state-of-the-art in
biomaterials-based antibody delivery systems and their applications in
cancer treatment are summarized, highlighting how the delivery systems augment the therapeutic efficacy of antibody drugs. The outlook and perspective on
biomaterials-based delivery of antitumor
antibodies are also discussed.