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Effect of opioid agonist-antagonist interaction on morphine dependence in rats.

Abstract
Morphine dependence was induced by treatment with morphine-admixed food (0.25mg/g of food) for 7 days. Withdrawal was precipitated by injecting naloxone (0.5mg/kg, s.c.). Rats treated with morphine exhibited body weight loss upon the naloxone injection. When morphine-dependent rats were injected subcutaneously with morphine, codeine, meperidine and pentazocine 30 min before the naloxone injection, these drugs significantly suppressed the naloxone-precipitated loss of body weight in a dose-dependent manner. However, body weight loss induced through coadministration of naloxone and Mr-2266 BS were not suppressed by morphine pretreatment. These results suggest that opioids protect against naloxone-precipitated loss of body weight, and that mu and kappa opiate receptors play an important role in the protection against naloxone-precipitated withdrawal.
AuthorsT Suzuki, Y Fukagawa, T Yoshii, S Yanaura
JournalLife sciences (Life Sci) Vol. 42 Issue 26 Pg. 2729-37 ( 1988) ISSN: 0024-3205 [Print] Netherlands
PMID3386409 (Publication Type: Journal Article)
Chemical References
  • Benzomorphans
  • Naloxone
  • MR 2266
  • Morphine
  • Meperidine
  • Pentazocine
  • Codeine
Topics
  • Animals
  • Benzomorphans (pharmacology)
  • Body Weight (drug effects)
  • Codeine (pharmacology)
  • Male
  • Meperidine (pharmacology)
  • Morphine (pharmacology)
  • Naloxone (pharmacology)
  • Pentazocine (pharmacology)
  • Rats
  • Substance Withdrawal Syndrome (physiopathology)
  • Substance-Related Disorders (physiopathology)

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