Orally administered
curcumin has been found to have a moderate
therapeutic effect on
dyslipidemia and
atherosclerosis. The present study was conducted to determine
lipid-modulating and antiatherosclerosis effects of
injectable curcumin in the rabbit model of
atherosclerosis induced by a high
cholesterol diet (HCD). New Zealand white male rabbits were fed on a normal chow enriched with 0.5% (w/w)
cholesterol for 8 weeks. Atherosclerotic rabbits were randomly divided into three groups, including a control group receiving intravenous (IV) injection of the saline
buffer, two treatment groups receiving IV administration of the
injectable curcumin at low (1 mg/kg/week) and high (10 mg/kg/week) over 4 weeks. Plasma
lipid parameters, including
low-density lipoprotein cholesterol (
LDL-C),
high-density lipoprotein cholesterol (HDL-C),
triglycerides (TG), and total
cholesterol (TC) were measured. Aortic arch atherosclerotic lesions were assessed using
hematoxylin and
eosin (H&E) staining. The low dose of
curcumin significantly reduced plasma levels of TC,
LDL-C, and TG by -14.19 ± 5.19%, -6.22 ± 1.77%, and - 29.84 ± 10.14%, respectively, and increased HDL-C by 14.05 ± 6.39% (p < 0.05). High dose of
curcumin exerted greater
lipid-modifying effects, in which plasma levels of TC,
LDL-C, and TG were significantly (p < 0.05) decreased by -56.59 ± 10.22%, -44.36 ± 3.24%, and - 25.92 ± 5.57%, respectively, and HDL-C was significantly increased by 36.24 ± 12.5%. H&E staining showed that the lesion severity was lowered significantly in the high dose (p = 0.03) but not significantly (p > 0.05) in the low-dose
curcumin groups, compared to control rabbits. The median (interquartile range) of plaque grades in the high dose and low dose, and control groups was found to be 2 [2-3], 3 [2-3], and 4 [3-4], respectively. The
injectable curcumin could significantly improve
dyslipidemia and alleviate atherosclerotic lesion in HCD-induced atherosclerotic rabbits.