Abstract | INTRODUCTION: METHODS: RESULTS: Compared with the sham group, the MCAO group induced severe pathological changes in the brain. The neurobehavior scores and infarct area in the brain were increased in the MCAO group than in the sham group. The apoptosis level in the MCAO group was also higher than in the sham group. However, after pretreatment with Met, the pathological changes in the brain were attenuated. Compared with the MCAO group, the pre-Met + MCAO group also had decreased neurobehavior scores and infarct area in the brain. Additionally, the apoptosis level in the pre-Met + MCAO group was lower than in the MCAO group. Moreover, the MCAO group had increased levels of LC3 and Beclin-1 than in the sham group. In the pre-Met + MCAO group, their levels were decreased than in the MCAO group. The p-AMPK level in the pre-Met + MCAO group was also increased than in the MCAO group, suggesting activation of p-AMPK by Met. CONCLUSION:
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Authors | Lu Wang, Aqian Wang, Hongtao Guo, Zhenxian Zhang, Shenghai Wang, Tengbo Pei, Zhiyong Liu, Dandan Yang, Yong Liu, Cailian Ruan |
Journal | European neurology
(Eur Neurol)
Vol. 84
Issue 3
Pg. 212-218
( 2021)
ISSN: 1421-9913 [Electronic] Switzerland |
PMID | 33845479
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2021 S. Karger AG, Basel. |
Chemical References |
- Neuroprotective Agents
- Metformin
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Topics |
- Animals
- Apoptosis
- Brain Injuries
- Brain Ischemia
(drug therapy)
- Humans
- Infarction, Middle Cerebral Artery
(drug therapy)
- Metformin
(pharmacology)
- Neuroprotective Agents
(pharmacology)
- Rats
- Rats, Sprague-Dawley
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