[Taurolidine for the prevention of catheter-related infections in children with intestinal insufficiency: preliminary experience in a Chilean tertiary hospital].

Abstract

BACKGROUND:

Taurolidine is a molecule with anti-endotoxic, anti-microbial and anti-inflammatory properties that inhibits bacterial adhesion, allowing for its use as lock therapy for the prevention of catheter-related bloodstream infections (CRBSI) in long-term central venous catheters (CVC).

AIM:

To report a preliminary experience, the first one in Chile, using lock therapy with taurolidine for the prevention of CRBSI and to report its efficacy.

METHOD:

A taurolidine-based solution was instilled in the CVC of three children with intestinal insufficiency dependent on parenteral nutrition, attended in a Chilean tertiary hospital, and the rate of CRBSI before and after its use was compared in retrospect.

RESULTS:

In the two patients who started lock therapy immediately after the installation of their CVC, the rate of CRBSI was brought to zero, whereas in the third patient, who had a 9 months-old CVC with a recurrent CRBSI history, an intercurrent CRBSI forced discontinuation of the prophylaxis.

CONCLUSIONS:

Lock therapy with a taurolidine-based solution prevented CRBSIs when it was begun immediately after installing the CVC, in contrast with an old CVC with a history of recurrent CRBSIs.

• Authors: Macarena Jordán P, César Haro, Alexa Puchi
• Journal: Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia (Rev Chilena Infectol) Vol. 38 Issue 1 Pg. 15-21 (Feb 2021) ISSN: 0717-6341 [Electronic] Chile
• Vernacular Title: Taurolidina para prevenir infecciones asociadas a catéter venoso central en niños con insuficiencia intestinal: experiencia preliminar en un hospital terciario chileno.
• PMID: 33844787 (Publication Type: Journal Article)

Chemical References

• Thiadiazines
• Taurine
• taurolidine

Topics

• Bacteremia
• Catheter-Related Infections (prevention & control)
• Catheterization, Central Venous (adverse effects)
• Child
• Chile
• Humans
• Infant
• Taurine (analogs & derivatives)
• Tertiary Care Centers
• Thiadiazines (therapeutic use)