Extracorporeal Shock Wave Therapy Promotes Osteogenic Differentiation in a Rabbit Osteoporosis Model.

Abstract

Extracorporeal shock wave therapy (ESWT) has been identified to accelerate bone formation. However, detailed mechanism has not been fully explained. In this study, we found that ESWT promoted osteoblast formation in vitro. Local ESW treatment of femur increased bone formation in vivo. Furthermore, changing the density or frequency of energy, there was no statistical difference in osteogenic differentiation. Therapeutically, local ESW therapy relieved bone loss and increased the number of bone trabecular in a rabbit osteoporosis model and promoted endogenous levels of SMAD2 protein expression. Thus, ESWT may be a potential therapy by promoting osteoblast maturation through TGF-β/SMAD2 pathway.

• Authors: Baofeng Li, Renkai Wang, Xianyin Huang, Yongliang Ou, Zhenyu Jia, Shanghui Lin, Ying Zhang, Hong Xia, Bei Chen
• Journal: Frontiers in endocrinology (Front Endocrinol (Lausanne)) Vol. 12 Pg. 627718 ( 2021) ISSN: 1664-2392 [Print] Switzerland
• PMID: 33841330 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 Li, Wang, Huang, Ou, Jia, Lin, Zhang, Xia and Chen.

Chemical References

• Smad2 Protein

Topics

• Animals
• Disease Models, Animal
• Extracorporeal Shockwave Therapy (methods)
• Femur (metabolism, physiopathology)
• Osteogenesis (physiology)
• Osteoporosis (physiopathology, therapy)
• Rabbits
• Smad2 Protein (metabolism)