Abstract | PURPOSE: Radical antegrade modular pancreatosplenectomy (RAMPS) has been reported to achieve high rates of a negative margin and resected metastatic lymph nodes. However, many studies have used historical controls and the results remain controversial. We conducted this study to compare the surgical and long-term outcomes of RAMPS vs. conventional distal pancreatectomy (DP). METHODS: The subjects of this multicenter retrospective study were 106 patients who underwent curative resection for left-sided pancreatic cancer between 2012 and 2017. Overall survival (OS) and recurrence-free survival (RFS) rates were compared using Kaplan-Meier estimates. RESULTS: The RAMPS group had more advanced T (T3/T4) and N stages (N1/N2) and a larger tumor size than the conventional group (T stage, p = 0.04; N stage, p = 0.02; tumor size, p = 0.04). The RAMPS group had more harvested metastatic lymph nodes (p = 0.02). After propensity-score matching, 37 patients from each group were included in the final analysis. There was no significant difference in RFS (p = 0.463) or OS (p = 0.383) between the groups. Multivariate analyses revealed the completion of chemotherapy to be an independent factor for RFS and OS (both p < 0.001). CONCLUSIONS: There was no difference in the RFS or OS between RAMPS and conventional DP in this series. RAMPS may be an option for R0 resection of advanced tumors; however, postoperative chemotherapy has a greater influence than the surgical procedure on the prognosis of patients with pancreatic cancer.
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Authors | Hyung Sun Kim, Tae Ho Hong, Young-Kyoung You, Joon Seong Park, Dong Sup Yoon |
Journal | Surgery today
(Surg Today)
Vol. 51
Issue 11
Pg. 1775-1786
(Nov 2021)
ISSN: 1436-2813 [Electronic] Japan |
PMID | 33830293
(Publication Type: Comparative Study, Journal Article)
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Copyright | © 2021. Springer Nature Singapore Pte Ltd. |
Topics |
- Aged
- Chemotherapy, Adjuvant
- Disease-Free Survival
- Female
- Humans
- Kaplan-Meier Estimate
- Lymph Node Excision
- Lymphatic Metastasis
(pathology)
- Male
- Margins of Excision
- Middle Aged
- Multicenter Studies as Topic
- Pancreas
(surgery)
- Pancreatectomy
(methods)
- Pancreatic Neoplasms
(drug therapy, mortality, pathology, surgery)
- Propensity Score
- Retrospective Studies
- Splenectomy
(methods)
- Treatment Outcome
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