6-Nitrocholesterol inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase and tumor cell growth.

Abstract

6-Nitrocholesterol has been shown to cause a 50% reduction in the level of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in animal cells in culture at 1.9 microM and it has relative binding affinity for the cytosolic oxysterol binding protein of 357 nM in cell-free extracts from the same cell line. In addition, significant cytotoxicity was observed when this sterol was incubated with hepatoma and lymphoma cells in culture.

• Authors: E J Parish, K L Dixon, S Chitrakorn, F R Taylor, B Luu, G Ourisson
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 153 Issue 2 Pg. 671-5 (Jun 16 1988) ISSN: 0006-291X [Print] United States
• PMID: 3382396 (Publication Type: Journal Article)

Chemical References

• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Receptors, Steroid
• oxysterol binding protein
• 6-nitrocholesterol
• Cholesterol

Topics

• Animals
• Cell Survival (drug effects)
• Cholesterol (analogs & derivatives, pharmacology)
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Mice
• Rats
• Receptors, Steroid (metabolism)
• Tumor Cells, Cultured