Fibroblast growth factor receptor 2 (FGFR2) fusions in Japanese patients with intrahepatic cholangiocarcinoma.

Abstract

OBJECTIVE:

Fibroblast growth factor receptor gene alterations have emerged as promising drug targets for intrahepatic cholangiocarcinoma, a rare cancer that has a poor prognosis. This study evaluated the frequency of fibroblast growth factor receptor 2 fusions in clinical specimens from Japanese patients with iCCA.

METHODS:

This study enrolled 116 patients who had histologically or cytologically confirmed adenocarcinoma and been diagnosed as relapsing after resection or with unresectable intrahepatic cholangiocarcinoma. We evaluated the frequency of fibroblast growth factor receptor 2 fusions-positive cells in their specimens using break-apart fluorescent in situ hybridization 'for 114 patients who met the study protocol'.

RESULTS:

Of a total of 114 cases, six (5.3%) were identified as fibroblast growth factor receptor 2 fusions-positive with a high frequency (87% or more) of fibroblast growth factor receptor 2 fusions-positive tumour cells whereas the remainder, with the exception of three cases with indeterminate results, were identified as fibroblast growth factor receptor 2 fusions-negative. The patients' baseline characteristics as well as their objective response rates, disease control rates, times to progression, and times to treatment failure with previous or ongoing first-line chemotherapy did not have any obvious relationship to the proportion of fibroblast growth factor receptor 2 fusions-positive case.

CONCLUSIONS:

Further detailed elucidation of fibroblast growth factor receptor 2 fusion status is expected to contribute to the development of promising therapeutic options for patients suffering from recurrent or unresectable intrahepatic cholangiocarcinoma.

• Authors: Masanori Tsujie, Tomohisa Iwai, Shoji Kubo, Takashi Ura, Etsuro Hatano, Daisuke Sakai, Yutaka Takeda, Masaki Kaibori, Tomoe Kobayashi, Akio Katanuma, Yu Katayose, Koji Fukase
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 51 Issue 6 Pg. 911-917 (May 28 2021) ISSN: 1465-3621 [Electronic] England
• PMID: 33822966 (Publication Type: Journal Article, Multicenter Study, Observational Study)
• Copyright: © The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• Oncogene Proteins, Fusion
• FGFR2 protein, human
• Receptor, Fibroblast Growth Factor, Type 2

Topics

• Adult
• Aged
• Aged, 80 and over
• Bile Duct Neoplasms (epidemiology, genetics, metabolism, pathology)
• Bile Ducts, Intrahepatic (metabolism, pathology)
• Cholangiocarcinoma (genetics, metabolism, mortality, pathology)
• Female
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease
• Humans
• In Situ Hybridization, Fluorescence
• Japan (epidemiology)
• Male
• Middle Aged
• Neoplasm Recurrence, Local (pathology)
• Oncogene Proteins, Fusion (genetics)
• Receptor, Fibroblast Growth Factor, Type 2 (genetics)