Changes of lymphocyte membrane fluidity in rheumatoid arthritis: a fluorescence polarisation study.

Abstract

Fluorescence polarisation of 1,6-diphenyl-1,3,5-hexatriene was used to study the lymphocyte membrane in rheumatoid arthritis. The increase of polarisation value in the patients (n = 27) compared with healthy controls (n = 32) suggests a decrease of membrane fluidity. Moreover, erythrocyte sedimentation rate (ESR) and plasma fibrinogen concentrations were positively correlated with lymphocyte fluorescence polarisation values (r = 0.66 and r = 0.76 respectively). The results suggest that the changes in lymphocyte membrane fluidity could be involved in the pathogenetic mechanism of rheumatoid arthritis.

• Authors: E Beccerica, G Piergiacomi, G Curatola, G Ferretti
• Journal: Annals of the rheumatic diseases (Ann Rheum Dis) Vol. 47 Issue 6 Pg. 472-7 (Jun 1988) ISSN: 0003-4967 [Print] England
• PMID: 3382266 (Publication Type: Journal Article)

Chemical References

• Diphenylhexatriene

Topics

• Adult
• Aged
• Arthritis, Rheumatoid (immunology)
• Diphenylhexatriene
• Female
• Fluorescence Polarization
• Humans
• Lymphocytes (ultrastructure)
• Male
• Membrane Fluidity
• Middle Aged