LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling.

Abstract

Nearly 2 decades since its discovery as one of the genes responsible for the Wolf-Hirschhorn Syndrome (WHS), the primary function of the leucine-zipper EF-hand containing transmembrane 1 (LETM1) protein in the inner mitochondrial membrane (IMM) or the mechanism by which it regulates mitochondrial Ca2+ handling is unresolved. Meanwhile, LETM1 has been associated with the regulation of fundamental cellular processes, such as development, cellular respiration and metabolism, and apoptosis. This mini-review summarizes the diversity of cellular functions impacted by LETM1 and highlights the multiple roles of LETM1 in health and disease.

• Authors: Gayathri K Natarajan, Jyotsna Mishra, Amadou K S Camara, Wai-Meng Kwok
• Journal: Frontiers in physiology (Front Physiol) Vol. 12 Pg. 637852 ( 2021) ISSN: 1664-042X [Print] Switzerland
• PMID: 33815143 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021 Natarajan, Mishra, Camara and Kwok.