Analgesia after operation. A controlled comparison of meptazinol, pentazocine and pethidine.

Abstract

In a double-blind investigation of the efficacy on pain following abdominal or orthopaedic surgery, meptazinol 100 mg, a new hexahydroazepine derivative, was found to be equipotent with pentazocine 60 mg and pethidine 100 mg when given i.m. Analgesia was maximal 30-60 min after injection and was still present at the end of 2 h. The duration of action of meptazinol was estimated to be 4 h. Meptazinol produced less sedation and a greater sparing of lung function tests than did pethidine and pentazocine. When meptazinol or morphine was administered for further pain relief in a single-blind manner there was no evidence of patient preference for one drug or the other.

• Authors: N J Paymaster
• Journal: British journal of anaesthesia (Br J Anaesth) Vol. 49 Issue 11 Pg. 1139-46 (Nov 1977) ISSN: 0007-0912 [Print] England
• PMID: 337984 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics
• Azepines
• Meperidine
• Pentazocine

Topics

• Adult
• Aged
• Analgesics (pharmacology)
• Azepines (therapeutic use)
• Clinical Trials as Topic
• Consciousness
• Double-Blind Method
• Female
• Humans
• Male
• Meperidine (therapeutic use)
• Middle Aged
• Pain, Postoperative (drug therapy)
• Pentazocine (therapeutic use)
• Respiration (drug effects)
• Time Factors