Abstract |
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is potentially curative for acute myeloid leukemia (AML). The inherent graft-versus- leukemia activity (GvL) may be optimized by donor lymphocyte infusions (DLI). Here we present our single-center experience of DLI use patterns and effectiveness, based on 342 consecutive adult patients receiving a first allo-HSCT for AML between 2009 and 2017. The median age at transplantation was 57 years (range 19-79), and the pre-transplant status was active disease in 58% and complete remission (CR) in 42% of cases. In a combined landmark analysis, patients in CR on day +30 and alive on day +100 were included. In this cohort (n=292), 93 patients received cryopreserved aliquots of peripheral blood-derived grafts for DLI (32%) and median survival was 55.7 months (2-year/5-year probability: 62%/49%). Median survival for patients receiving a first dose of DLI "preemptively," in the absence of relapse and guided by risk marker monitoring (preDLI; n=42), or only after hematological relapse (relDLI; n=51) was 40.9 months (2-year/5-year: 64%/43%) vs 10.4 months (2-year/5-year: 26%/10%), respectively. Survival was inferior when preDLI was initiated at a time of genetic risk marker detection vs mixed chimerism or clinical risk only. Time to first-dose preDLI vs time to first-dose relDLI was similar, suggesting that early warning and intrinsically lower dynamics of AML recurrence may contribute to effectiveness of preDLI-modified GvL activity. Future refinements of the preemptive DLI concept will benefit from collaborative efforts to diagnose measurable residual disease more reliably across the heterogeneous genomic spectrum of AML.
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Authors | Andrés R Rettig, Gabriele Ihorst, Hartmut Bertz, Michael Lübbert, Reinhard Marks, Miguel Waterhouse, Ralph Wäsch, Robert Zeiser, Justus Duyster, Jürgen Finke |
Journal | Annals of hematology
(Ann Hematol)
Vol. 100
Issue 9
Pg. 2339-2350
(Sep 2021)
ISSN: 1432-0584 [Electronic] Germany |
PMID | 33796897
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s). |
Topics |
- Adult
- Aged
- Female
- Hematopoietic Stem Cell Transplantation
- Humans
- Leukemia, Myeloid, Acute
(therapy)
- Lymphocyte Transfusion
- Male
- Middle Aged
- Tissue Donors
- Transplantation, Homologous
- Treatment Outcome
- Young Adult
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