Ocular tolerance of bacillus Calmette-Guerin organisms.

Abstract

The results of this investigation indicate that 5 X 10(6) and 5 X 10(8) viable bacillus Calmette-Guerin (BCG) organisms (Mycobacterium bovis strain) can be safely administered in the subconjunctival region of the eye of New Zealand albino rabbits without producing toxic effects locally or within the eye. This study provides a format for testing the applicability of BCG immunotherapy for experimental melanomas.

• Authors: J Rutgard, M Frenkel, G A Peyman, S Saks, A Stankevych
• Journal: Archives of ophthalmology (Chicago, Ill. : 1960) (Arch Ophthalmol) Vol. 95 Issue 12 Pg. 2210-3 (Dec 1977) ISSN: 0003-9950 [Print] United States
• PMID: 337945 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• BCG Vaccine

Topics

• Animals
• BCG Vaccine
• Conjunctiva (microbiology)
• Eye (immunology)
• Eye Neoplasms (therapy)
• Female
• Immunotherapy
• Inflammation (pathology)
• Injections
• Melanoma (therapy)
• Mycobacterium bovis (immunology)
• Neoplasms, Experimental (therapy)
• Rabbits
• Sclera (pathology)