Abstract | BACKGROUND: METHODS: We retrospectively investigated consecutive elderly metastatic PC patients (≥ 75 years) treated with chemotherapy at our institution between January 2015 and April 2020. Skeletal muscle index was calculated at the third lumbar vertebra using pretreatment computed tomography. We evaluated time to treatment failure (TTF), progression-free survival (PFS), overall survival (OS), early treatment discontinuation, relative dose intensity (RDI), and severe adverse events (AEs). RESULTS: Among 80 patients included ( gemcitabine plus nab-paclitaxel [GnP] 52; gemcitabine 21; S1 6; modified FOLFIRINOX 1), cachexia and sarcopenia were present in 48 (60%) and 61 (76%) patients, respectively. Cachexia was associated with older age, worse performance status, higher level of neutrophil to lymphocyte ratio, worse nutritional status, and shorter TTF and PFS. Furthermore, it was also associated with early treatment discontinuation, reduced RDI of nab-paclitaxel, and increased incidence of grade 4 neutropenia in patients receiving GnP. On the other hand, sarcopenia had less impact on the clinical course of elderly PC patients. CONCLUSIONS: In our experience, cachexia was considered an effective tool in the management of elderly PC patients receiving palliative chemotherapy.
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Authors | Tsuyoshi Takeda, Takashi Sasaki, Chisaki Suzumori, Takafumi Mie, Takaaki Furukawa, Yuto Yamada, Akiyoshi Kasuga, Masato Matsuyama, Masato Ozaka, Naoki Sasahira |
Journal | International journal of clinical oncology
(Int J Clin Oncol)
Vol. 26
Issue 7
Pg. 1293-1303
(Jul 2021)
ISSN: 1437-7772 [Electronic] Japan |
PMID | 33791917
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects)
- Cachexia
(drug therapy, etiology)
- Humans
- Paclitaxel
(therapeutic use)
- Pancreatic Neoplasms
(complications, drug therapy)
- Retrospective Studies
- Sarcopenia
(complications)
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