Fucoxanthin Prevents Colorectal Cancer Development in Dextran Sodium Sulfate-treated Apc Min/+ Mice.

Abstract

BACKGROUND/AIM:

A xanthophyll of fucoxanthin (Fx) is a potential chemopreventive agent. Familial adenomatous polyposis (FAP) is an inherited disease that is associated with a high risk of developing colorectal cancer. However, it remains unclear whether Fx can modify colorectal tumorigenesis in ApcMin/+ mice, a model mouse for human FAP.

MATERIALS AND METHODS:

We investigated the chemopreventive effect of Fx in dextran sodium sulfate (DSS)-treated ApcMin/+ mice.

RESULTS:

Administration of Fx in the diet for 5 weeks significantly suppressed the number of colorectal adenocarcinomas in DSS-treated male ApcMin/+ mice, although the treatment did not affect the occurrence of colorectal dysplastic crypts and adenoma in the mice. In addition, Fx down-regulated cyclin D1 expression (0.6-fold) in colorectal mucosa of ApcMin/+ mice when compared with that of the control mice.

CONCLUSION:

Fx possesses chemopreventive potential against progression of colorectal carcinogenesis in ApcMin/+ mice that receive inflammatory stimuli.

• Authors: Masaru Terasaki, Takahiro Hamoya, Atsuhito Kubota, Hiroyuki Kojima, Takuji Tanaka, Hayato Maeda, Kazuo Miyashita, Michihiro Mutoh
• Journal: Anticancer research (Anticancer Res) Vol. 41 Issue 3 Pg. 1299-1305 (Mar 2021) ISSN: 1791-7530 [Electronic] Greece
• PMID: 33788721 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Anticarcinogenic Agents
• Ccnd1 protein, mouse
• Xanthophylls
• fucoxanthin
• Cyclin D1
• Dextran Sulfate

Topics

• Adenomatous Polyposis Coli (complications)
• Animals
• Anticarcinogenic Agents (administration & dosage)
• Colorectal Neoplasms (chemically induced, prevention & control)
• Cyclin D1 (analysis, physiology)
• Dextran Sulfate
• Disease Models, Animal
• Male
• Mice
• Xanthophylls (administration & dosage)