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Assessment, prevalence, and correlates of frailty among middle-aged adults with HIV in rural Uganda.

Abstract
We investigated the prevalence and risk factors for frailty among people with HIV (PWH) in rural Uganda (n = 55, 47% male, mean age 44 years). Frailty was defined according to the Fried criteria with self-reported physical activity level replacing the Minnesota Leisure Time Activity Questionnaire. Alternate classifications for physical activity utilized were the sub-Saharan Africa Activity Questionnaire and the International Physical Activity Questionnaire. Eleven participants (19%) were frail. Frail participants were older (p < 0.001), less likely to be on antiretroviral therapy (p = 0.03), and had higher rates of depression (p < .001) and HIV-associated neurocognitive disorder (p = 0.003). Agreement between physical activity measures was sub-optimal. Prevalence of frailty was high among PWH in rural Uganda, but larger sample sizes and local normative data are needed.
AuthorsAlyssa Vecchio, Gertrude Nakigozi, Noeline Nakasujja, Alice Kisakye, James Batte, Richard Mayanja, Aggrey Anok, Kevin Robertson, Maria J Wawer, Ned Sacktor, Leah H Rubin, Deanna Saylor
JournalJournal of neurovirology (J Neurovirol) Vol. 27 Issue 3 Pg. 487-492 (06 2021) ISSN: 1538-2443 [Electronic] United States
PMID33788138 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-HIV Agents
Topics
  • Activities of Daily Living (psychology)
  • Adult
  • Aged
  • Anti-HIV Agents (therapeutic use)
  • Antiretroviral Therapy, Highly Active
  • Cross-Sectional Studies
  • Depression (complications, drug therapy, epidemiology, physiopathology)
  • Exercise (physiology)
  • Female
  • Frailty (complications, drug therapy, epidemiology, physiopathology)
  • HIV Infections (complications, drug therapy, epidemiology, physiopathology)
  • Humans
  • Male
  • Middle Aged
  • Neurocognitive Disorders (complications, drug therapy, epidemiology, physiopathology)
  • Prevalence
  • Risk Factors
  • Rural Population
  • Surveys and Questionnaires
  • Uganda (epidemiology)

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