[Brevikarin dihydrochloride--a new original anti-arrhythmia agent].

Abstract

On six models of arrhythmias of atrial and ventricular types (induced by administration of aconitine, chlorcalcium, chlorbarium, strophanthin, chloroform-adrenaline and by coronary occlusion) it was shown that in rats, cats and rabbits the antiarrhythmic, preventive and relieving activity of brevicarine dichlorhydrate exceeded that of quinidine, novocainamide and lidocaine in power by 3-5 times and in duration by 3-18 times.

• Authors: P P Denisenko, T V Vinogradova, A A Semenov
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1988 Mar-Apr Vol. 51 Issue 2 Pg. 50-3 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Brevikarin dikhlorgidrat--novoe original'noe protivoaritmicheskoe sredstvo.
• PMID: 3378605 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Alkaloids
• Anti-Arrhythmia Agents
• Indoles
• brevicarine
• Lidocaine
• Quinidine
• Procainamide

Topics

• Alkaloids (therapeutic use)
• Animals
• Anti-Arrhythmia Agents (therapeutic use)
• Arrhythmias, Cardiac (chemically induced, drug therapy, prevention & control)
• Cats
• Drug Evaluation, Preclinical
• Indoles
• Lidocaine (therapeutic use)
• Male
• Plants, Medicinal
• Procainamide (therapeutic use)
• Quinidine (therapeutic use)
• Rabbits
• Rats