Abstract |
The specific angiotensin receptor antagonist, Sar1, Thr8AII ( sarthran), was infused intracerebroventricularly in alert spontaneously hypertensive rats (SHR), and Wistar-Kyoto (WKY) and Sprague-Dawley (SD) normotensive rat strains. This resulted in a mean decrease of 35 mm Hg in the SHR group by 25 min post-infusion, and corresponding decreases in the WKY and SD rats of 13 and 15 mm Hg, respectively. A prominent transient sarthran-induced elevation in blood pressure was noted in the SHR group during the 5-min infusion. This agonistic effect was not observed in members of the WKY and SD strains. These data encourage the use of sarthran as a valuable pharmacological probe in the examination of the role of the brain renin-angiotensin system in hypertension.
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Authors | L L Jensen, J W Harding, J W Wright |
Journal | Brain research
(Brain Res)
Vol. 448
Issue 2
Pg. 359-63
(May 17 1988)
ISSN: 0006-8993 [Print] Netherlands |
PMID | 3378158
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Receptors, Angiotensin
- Angiotensin II
- angiotensin II, Sar(1)-Thr(8)-
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Topics |
- Angiotensin II
(analogs & derivatives, pharmacology)
- Animals
- Blood Pressure
(drug effects)
- Brain
(drug effects, physiology)
- Injections, Intraventricular
- Male
- Rats
- Rats, Inbred SHR
(physiology)
- Rats, Inbred Strains
(physiology)
- Receptors, Angiotensin
(drug effects, physiology)
- Time Factors
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