Novel Radiation Approaches.

Abstract

The standard of care treatment for glioblastoma is surgical resection followed by radiotherapy to 60 Gy with concurrent and adjuvant temozolomide with or without tumor-treating fields. Advanced imaging techniques are under evaluation to better guide radiotherapy target volume delineation and allow for dose escalation. Particle therapy, in the form of protons, carbon ions, and boron neutron capture therapy, are being assessed as strategies to improve the radiotherapeutic ratio. Stereotactic, hypofractionated, pulsed-reduced dose-rate, and particle radiotherapy are re-irradiation techniques each uniquely suited for different clinical scenarios. Novel radiotherapy approaches, such as FLASH, represent promising advancements in radiotherapy for glioblastoma.

• Authors: Rupesh Kotecha, Martin C Tom, Minesh P Mehta
• Journal: Neurosurgery clinics of North America (Neurosurg Clin N Am) Vol. 32 Issue 2 Pg. 211-223 (Apr 2021) ISSN: 1558-1349 [Electronic] United States
• PMID: 33781503 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• Temozolomide

Topics

• Brain Neoplasms (radiotherapy)
• Glioblastoma (radiotherapy)
• Humans
• Temozolomide