Effect of the anti-oestrogen tamoxifen on the development of renal cortical necrosis induced by oestrone + vasopressin administration in rats.

Abstract

Bilateral renal cortical necrosis was observed after vasopressin administration in rats pretreated with oestrone acetate. Histochemical (succinic dehydrogenase, trichrome, periodic acid Schiff) and electronmicroscopic methods were used to examine how the anti-oestrogen, Tamoxifen, influences the development of this renal cortical necrosis. The experiments revealed that in most rats vasopressin did not induce renal tubular necrosis if the anti-oestrogen was administered simultaneously, even during oestrogen pretreatment. The results suggest that oestrogen receptors in the kidney are involved in the induction of renal cortical necrosis by vasopressin.

• Authors: J Kocsis, G Karácsony, S Karcsú, F A László
• Journal: British journal of experimental pathology (Br J Exp Pathol) Vol. 69 Issue 2 Pg. 157-67 (Apr 1988) ISSN: 0007-1021 [Print] England
• PMID: 3377960 (Publication Type: Journal Article)

Chemical References

• Tamoxifen
• Estrone
• Lypressin
• Succinate Dehydrogenase

Topics

• Animals
• Cell Membrane (ultrastructure)
• Epithelium (ultrastructure)
• Estrone (antagonists & inhibitors, pharmacology)
• Kidney Cortex (ultrastructure)
• Kidney Cortex Necrosis (chemically induced, enzymology, pathology)
• Lypressin (antagonists & inhibitors, pharmacology)
• Male
• Microscopy, Electron
• Rats
• Succinate Dehydrogenase (metabolism)
• Tamoxifen (pharmacology)