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Immunohistochemical diagnosis of sinonasal melanoma, carcinoma, and neuroblastoma with monoclonal antibodies HMB-45 and anti-synaptophysin.

Abstract
The efficacy of two new monoclonal antibodies with cell lineage-restricted reactivity (HMB-45 [melanocytes] and anti-synaptophysin [neuroepithelial cells]) was compared with that of "traditional" antibody panels in the delineation of malignant melanoma (MM) of the sinonasal region, nasopharyngeal carcinoma (NPC), and olfactory neuroblastoma (ONBL). HMB-45 recognized all of eight melanomas and stained one of five neuroblastomas, but failed to label any of 12 cases of NPC. All examples of ONBL were stained by anti-synaptophysin; other tumors were nonreactive with this reagent. A panel of antibodies to cytokeratin, vimentin, epithelial membrane antigen, and S100 protein was also effective in discriminating between MM, NPC and ONBL. These results suggest that HMB-45 and anti-synaptophysin are comparable in utility to more extended antibody panels in the diagnosis of sinonasal malignancies, but only if used in combination with one another.
AuthorsM R Wick, S J Stanley, P E Swanson
JournalArchives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 112 Issue 6 Pg. 616-20 (Jun 1988) ISSN: 0003-9985 [Print] United States
PMID3377660 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • anti-synaptophysin
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Monoclonal
  • Antibody Specificity
  • Brain Neoplasms (diagnosis, pathology)
  • Carcinoma (diagnosis, pathology)
  • Diagnosis, Differential
  • Evaluation Studies as Topic
  • Female
  • Humans
  • Male
  • Melanoma (diagnosis, pathology)
  • Middle Aged
  • Nasopharyngeal Neoplasms (diagnosis, pathology)
  • Neuroblastoma (diagnosis, pathology)
  • Nose Neoplasms (diagnosis, pathology)
  • Olfactory Bulb
  • Paranasal Sinus Neoplasms (diagnosis, pathology)

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