[Study of the Thomsen-Friedenreich antigen in bladder tumors].

Abstract

Thomsen Friedenreich antigen (T-ag), ABH isoantigen (ABH-ag) in 106 cases with bladder tumor (all transitional cell carcinoma) of various histological grades and stages were investigated by the Avidin-Biotin-Peroxidase Complex (ABC) method. There was a correlation between histological grade, stage and deletion of the antigenicity (T-ag and ABH-ag). In a follow-up study of 45 patients with low grade and low stage tumor, the recurrence rate after surgery of the cases with abnormal antigenicity (T-ag and ABH-ag) was significantly higher than that of the cases with the normal antigenicity. Combination of two markers (T-ag and ABH-ag) was significantly more effective than the single marker.

• Authors: H Fukatsu, H Yamada, H Nonomura, Y Miyagawa, M Waki, Y Hatano, S Hiraiwa, T Muramatsu, E Nishikawa, Y Yamada
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 34 Issue 2 Pg. 260-7 (Feb 1988) ISSN: 0018-1994 [Print] Japan
• PMID: 3376818 (Publication Type: English Abstract, Journal Article)

Chemical References

• ABO Blood-Group System
• Antigens, Neoplasm
• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor
• Disaccharides
• Thomsen-Friedenreich antigen

Topics

• ABO Blood-Group System (analysis)
• Antigens, Neoplasm (analysis)
• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor (analysis)
• Carcinoma, Transitional Cell (immunology)
• Disaccharides (analysis)
• Humans
• Urinary Bladder Neoplasms (immunology)